Posted by: Janine | May 19, 2011

Medicinal Chemistry

Bad carcinogen
Cannot kill the best enzyme
for its own demise.

Laura Shireman

University of Washington

My Ph.D. in medicinal chemistry focused on the mechanistic enzymology of glutathione transferases, a class of drug-metabolizing enzyme. One chapter focused on a gnarly carcinogen, 4-hydroxynonenal, that mucks up the works for all kinds of proteins in the body, including enzymes that metabolize it. However, the glutathione transferase that metabolizes and thereby detoxifies 4-hydroxynonenal with the highest catalytic efficiency, GST A4-4, also resists its adduction.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

Categories

%d bloggers like this: