Posted by: Janine | May 19, 2011

Medicinal Chemistry

Bad carcinogen
Cannot kill the best enzyme
for its own demise.

Laura Shireman

University of Washington

My Ph.D. in medicinal chemistry focused on the mechanistic enzymology of glutathione transferases, a class of drug-metabolizing enzyme. One chapter focused on a gnarly carcinogen, 4-hydroxynonenal, that mucks up the works for all kinds of proteins in the body, including enzymes that metabolize it. However, the glutathione transferase that metabolizes and thereby detoxifies 4-hydroxynonenal with the highest catalytic efficiency, GST A4-4, also resists its adduction.


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